但是关于这篇文章的结论,来自南加州大学凯克医学院的J. Gage Crump课题组和来自荷兰皇家科学院Hubrecht研究所的Jeroen Bakkers课题组(以下简称为Tessadori等)提出了质疑,并于2020年9月23日于Nature杂志上发表题为“Zebrafish prrx1a mutants have normal hearts”的文章【3】,表示没有发现prrx1a在建立驱动斑马鱼心脏环化的右旋信号通路中的作用。
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